Detrol

What is DETROL?

DETROL is used for the treatment of the symptoms of overactive bladder, which include frequency, urgency, and urge incontinence.

What does DETROL do?

Tolterodine (the active ingredient in DETROL) prevents bladder contractions or spasms. This results in more bladder capacity and less frequency, urgency and involuntary loss of urine.

What are the ingredients in DETROL?

Each tablet contains 1 mg or 2 mg of the active ingredient tolterodine L-tartrate.

Each tablet also contains the following nonmedicinal ingredients: colloidal anhydrous silica, calcium hydrogen phosphate dihydrate, hypromellose, magnesium stearate, cellulose microcrystalline, sodium starch glycolate, stearic acid, and titanium dioxide.

How do I store DETROL?

• Store at room temperature 15^oC to 30^oC.
• You should not use your medication after the expiration date printed on the carton and label.
• Keep all medications out of the reach of children. This medication could harm them.

Learn More: Taking this medication >

How do I take DETROL?

Take DETROL as instructed by your doctor. Do not increase, decrease or stop taking DETROL without first talking to your doctor. The usual starting dose is 2 mg twice daily, but may be decreased to 1 mg twice daily.

When should DETROL not be used?

You should not take DETROL if you have:

• urinary retention
• gastric retention
• uncontrolled narrow angle glaucoma
• known hypersensitivity to the tolterodine L-tartrate or any of the other ingredients

What if I miss a dose?

If you should forget to take your tablet at the usual time, take it as soon as you remember unless it is time to take the next one. Continue with the remaining doses as before. Do not take more than one dose at a time.

What should I do in case of an overdose?

Do not take more tablets than your doctor has told you to. If you take too many tablets by accident, call your doctor or pharmacist or a Poison Control Centre immediately.

Can I take DETROL with other medications?

The following list includes some, but not all, of the drugs that may increase the risk of side effects while taking DETROL. You should check with your doctor or pharmacist before taking any other medication with DETROL.

Drugs that may interact with DETROL include:

• other drugs that possess antimuscarinic/anticholinergic properties (drugs that cause blurred vision, constipation, dry mouth, etc.)
• antifungals (drugs to treat fungal infections, such as fluconazole, ketoconazole, or itraconazole)
• antibiotics (i.e., erythromycin, clarithromycin)
• cyclosporine (a drug to prevent rejection of organ transplants)
• vinblastine (a drug to treat some types of cancer)
• antiarrhythmics (drugs that stabilize the heart rhythm function, such as procainamide, quinidine, amiodarone, sotalol, etc.)
• antidepressants (mood disorder drugs)
• antipsychotics (drugs to stabilize thinking and behavior)
• anti-asthmatic (salmeterol)

Learn More: Safety information >

What are the side effects of DETROL?

As with most drugs, DETROL can cause some side effects.

Tell your doctor or pharmacist right away if you suffer from any of the following side effects while taking this medication:

• dry mouth
• decreased tear production (dry irritable eye)
• heartburn
• blurred vision
• dizziness
• palpitations (sensation of rapid, pounding, or irregular heart beat)
• fainting
• difficulty in urination (passing water)

The most common side effects are dry mouth and headache. Less commonly reported side effects are dizziness, fatigue, abdominal pain, constipation and heartburn.

If you experience any symptoms of a possible heart rhythm disturbance, such as dizziness, palpitations (sensation of rapid, pounding, or irregular heart beat), fainting, or seizures, you should stop taking DETROL and seek immediate medical attention.

Check with your doctor or pharmacist right away if you have any bothersome or unusual effects while taking DETROL.

Use caution while driving or using machinery until you know how DETROL affects you.

Allergic reactions are uncommon. If you experience one, stop taking DETROL and call your doctor or pharmacist.

This is not a complete list of side effects. For any unexpected effects while taking DETROL, stop taking the drug and contact your doctor or pharmacist.

Are there any serious warnings or precautions that I should know about?

DETROL may have an effect on the electrical activity of the heart. This effect can be measured as a change in the electrocardiogram (ECG).

It is important to follow the instructions of your doctor with regard to dosing or any special tests. In very rare cases, drugs with an effect on the ECG can lead to disturbances in heart rhythm (arrhythmias/dysrhythmias). These heart rhythm disturbances are more likely in patients with risk factors, such as heart disease, or in the presence of certain interacting drugs.

If you experience any symptoms of a possible heart rhythm disturbance, such as dizziness, palpitations (sensation of rapid pounding, or irregular heart beat), fainting, or seizures, you should stop taking DETROL and seek immediate medical attention.

BEFORE you use DETROL talk to your doctor or pharmacist if:

• you are pregnant, or trying to become pregnant
• you are breastfeeding your child
• you have myasthenia gravis (a chronic autoimmune neuromuscular disease, which cause muscle weakness)
• you have stomach problems affecting passage and digestion of food
• you have liver problems
• you have kidney problems
• you are taking medication bought without a prescription. They may affect your condition, or how DETROL works for you.
• you are a female or are over 65 years in age; you have a disorder known as Long QT Syndrome; a heart disease; a history of stroke or brain hemorrhage; a personal history of fainting spells; a family history of sudden cardiac death at <50 years; electrolyte disturbances (e.g., low blood potassium levels); an eating disorder or are following an extreme diet; diabetes, especially with associated nerve disorders